It's very simple: ALWAYS use blue Locktite for metal screws to metal holes, actually all metal - to - metal connections.
NEVER use blue Locktite to plastic - to - plastic or plastic - to - metal connections.
Blue Locktite can only work if in between two metal connections, and only then it will cure and create a bond. If used on plastic, it will never harden out and will act like a lubricant....making it easier for the screw to get loose. Best bet is to tighten a metal screw in plastic just tight, but not too tight otherwise you strip the thread.
Should this happen, apply 2 or 3 layers of thick CA glue to the hole and let it get dry over night. The next day you should be fine....