I am not familiar with a Bumblebee, but the principle of of initial set-up is almost always the same, regardless of the equipment use.
Even in case you know already:
First step is to create a new model in your transmitter (airplane, no mixers, all trim to 0...)
Second step (at least I do it that way with equipment I didn't use before) I hook an old servo to each channel of my receiver to see if the channels are working - if later on I get problems, at least I know that side is OK.
Third step is to calibrate the ESC's. That can be done with Flight Control already wired in, or just by hooking the ESC's directly to the transmitter (my preffered method). The important thing to know is that different ESC's demand different procedures to be calibrated. So you have to find out (Google) what brand and model
your ESC is, and how it needs to be set up. In case there is no "special" treatment for your ESC, do it like tstrike suggested - thats "standard procedure" :
Take off your props, put an esc into the throttle port on your bound rec., slide throttle all the way up, turn on your tx, power up your rec., wait for the two beeps, slide throttle down, wait for single beep, unplug rec., repeat on all esc's
this teaches your esc's what top and bottom throttle range is from your transmitter (tx).
PS: If the receiver and the GAUI are having power without the ESC's being connected, you need to remove the red (power) wire of the ESC
Chris