I use an EMAX 4in1 25A, so can't really share experience. I do like the fact it makes for a clean build. In retrospect, I would have liked a Q-Brain (or Quattro) better than the EMAX, for the latter is quite thick (and has protruding screws). I had to get creative on my SK S500 frame to fit it inbetween the upper and lower plates.
One thing which I do like about the EMAX is that the ESC's are modular, so you can replace them if needed. As far as I know Q-Brain does not have this feature.
If you can place the unit on a central spot on your frame, it can benefit de COG and has a small footprint.